Bridge-Induced Translocation between NUP145 and TOP2 Yeast Genes Models the Genetic Fusion between the Human Orthologs Associated With Acute Myeloid Leukemia

In mammalian organisms liquid tumors such as acute myeloid leukemia (AML) are related to spontaneous chromosomal translocations ensuing in gene fusions.We previously developed a system named bridge-induced translocation (BIT) that allows linking together two different chromosomes exploiting the strong endogenous homologous recombination system of t

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A peep into the transcriptome studies of the industrially important brown algae with special focus on Macrocystis genus

Brown algae are a commercial source of different polysaccharides/hydrocolloids that has been used to produce food, pharmaceutical, tenga air-tech regular and several other useful biotechnological stuff.Nevertheless, transcriptomics has become a tool that not only provides valuable information for the understanding of the diamondbacks retro hat phys

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AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles

Summary: The autophagy pathway is an essential facet of the innate immune response, capable of rapidly targeting intracellular bacteria.However, the initial signaling regulating autophagy induction in response to pathogens remains largely unclear.Here, we report that AMPK, an upstream activator of the autophagy pathway, is stimulated upon detection

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